Symbol
Name
ID

Atr
ataxia telangiectasia and Rad3 related
MGI:108028

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Anorexia	Pachygyria	Large basal ganglia	Cerebellar vermis hypoplasia	Hyperactivity	Intellectual disability	Seizure
Disease(s) Associated with ATR	Microcephaly	Anorexia	Pachygyria	Large basal ganglia	Cerebellar vermis hypoplasia	Hyperactivity	Intellectual disability	Seizure
pancreatic cancer
Seckel syndrome 1

Mouse Phenotypes

increased neuron apoptosis

abnormal neuron proliferation

decreased cerebellar granule cell precursor proliferation

abnormal brain morphology

abnormal cerebellum development

abnormal rhombic lip morphology

decreased brain weight

decreased brain size

abnormal corpus callosum morphology

absent corpus callosum

hippocampus hypoplasia

abnormal cerebral cortex morphology

abnormal stratification in cerebral cortex

abnormal olfactory bulb granule cell layer morphology

ectopic Purkinje cell

abnormal cerebellar granule layer morphology

decreased cerebellar granule cell number

abnormal astrocyte morphology

abnormal embryonic/fetal subventricular zone morphology

abnormal spinal cord morphology

Availability

Mouse Genotype

Atr^tm1Ofc/Atr^tm1Ofc

Atr^{tm1b(KOMP)Wtsi}/Atr⁺

Atr^tm2Bal/Atr^tm2Bal
Tg(Nes-cre)1Kln/0 (conditional)

Atr^tm2Bal/Atr^tm2Bal
Emx1^tm1(cre)Krj/Emx1⁺ (conditional)

Atr^tm2Bal/Atr^tm2Bal
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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